Is there a Genetic Predispisition to Gout?
by: Arlene Gentallan
Thanks to the Nobel Prize winning research done by Bill Guggino, Joe Coresh and colleagues, it is now recognized that a genetic defect can lead to the development of Gout.
Specifically a defect in the ABCG2 gene of an individual. This is the gene responsible for the transport of urate (uric acid) out of the cell.
Our kidneys facilitate the elimination of uric acid through urination but when ABCG2 gene fails to kick out urate out of the cells, instead of being flushed out, uric acid accumulates in the blood to be deposited in different areas of the body such as joint spaces, leading a person to develop Gout.