What is the difference between COX-1 and COX-2?
What is the difference between Cyclooxygenase-1 (COX-1) and Cyclooxygenase-2 (COX-2)?
by: Arlene Gentallan
Cyclooxygenase (COX) is an enzyme that plays a key role in the formation of prostanoids such as prostaglandins, prostacyclin and thromboxane--which are involve in inflammatory response (pain, swelling, redness, increase heat, and loss of function.) Prostaglandins are formed from arachidonic acid.
What is the difference between COX-1 and COX-2?
Cyclooxygenase-1 (COX-1):
Presence in the body: It is produced at a constant rate by the body for it's normal functioning.
Purpose:
Location: Predominantly found in the stomach, kidneys, and platelets.
Cyclooxygenase-2 (COX-2):
Presence in the body: Not usually present in the body unless triggered by the immune system.
Purpose: Responsible for the production of prostaglandin which is involve in inflammation, pain, and fever.
Location: Commonly located at macrophages, leukocytes and fibroblasts at the site of inflammation.
SUMMARY:
Cyclooxygenase-1 (COX-1) is important to maintain the function of body organs such as stomach, kidneys, and platelet; while Cyclooxygenase-2 (COX-2) is primarily involve with inflammation and pain.
by: Arlene Gentallan
Cyclooxygenase (COX) is an enzyme that plays a key role in the formation of prostanoids such as prostaglandins, prostacyclin and thromboxane--which are involve in inflammatory response (pain, swelling, redness, increase heat, and loss of function.) Prostaglandins are formed from arachidonic acid.
What is the difference between COX-1 and COX-2?
Cyclooxygenase-1 (COX-1):
Presence in the body: It is produced at a constant rate by the body for it's normal functioning.
Purpose:
- Regulates gastric acidity
- Protects the gastrointestinal mucosa
- Regulates water secretion by the kidneys
- Blood clotting.
- COX-1 is involve in the production of prostaglandin that is essential for the everyday functioning.
Location: Predominantly found in the stomach, kidneys, and platelets.
Cyclooxygenase-2 (COX-2):
Presence in the body: Not usually present in the body unless triggered by the immune system.
Purpose: Responsible for the production of prostaglandin which is involve in inflammation, pain, and fever.
Location: Commonly located at macrophages, leukocytes and fibroblasts at the site of inflammation.
SUMMARY:
Cyclooxygenase-1 (COX-1) is important to maintain the function of body organs such as stomach, kidneys, and platelet; while Cyclooxygenase-2 (COX-2) is primarily involve with inflammation and pain.
