Psychedelics Boosts Neuroplasticity

Neuroplasticity is the remarkable ability of the brain to rewire itself. Knowing that the brain can heal itself revolutionizes the way we understand the human brain and opens possibility to find better ways on how the brain can do so. Research by Olson and colleagues explored the extraordinary ability of peychodelic drugs in promoting neuroplasticity.

Research found that psychedelics holds therapeutic potential to manage anxiety, depression, and addiction which is linked to it's ability to promote neuroplasticity.

Psychedelics Boosts Neuroplasticity
Psychedelics Boosts Neuroplasticity

@healthbiztips by Arlene Gentallan

The development of depression and other anxiety disorder such as post-traumatic stress disorder (PTSD) is associated with the shrinkage of neurons in the area of the brain called the prefrontal cortex. It is believed that the anesthetic ketamine and certain serotonergic psychedelics works by stimulating neuron growth in the prefrontal cortex.

The study reveal that psychedelic drugs LST, DMT, and  DOI promote neuroplasticity in animal experiments, leading to stimulation of growth of dendrites of a neuron and establishment of better connections between them. Not all kinds of psychedelic drugs promotes neuroplasticity like ibogaine. Ibogaine did not promote brain rewiring, but it's derivative noribogaine, did. Psychedelic medicine rewires the brain by stimulating the TrkB, mTOR, and 5-HT2A signaling pathways.

Study shows that psychodelics can provide a fast and long-lasting effect against anxiety and depression with just a single dose.


What are psychodelics?

The word psychodelic came from the Greek words "psyche" which means mind, and "deleine" which means to manifest. Psychodelic is a kind of drug that can cause an altered level of consciousness, and disturbed sensory perception such as hallucinations. Many of the psychodelics drugs are illegal to use worldwide.


It is imperative to find better ways to treat depression and anxiety considering one in every three patients do not respond to conventional anti-depressant and anxiolytic drugs. Althought psychodelics may seem like a promising treatment for anxiety and depressive disorder, further study is still needed.



Resources:

Ly, c., Greb. A., et al. (2018). Psychedelics Promote Structural and Functional Neural Plasticity. Cell Reports. Volume 23, Issue 11, p3170–3182. DOI: https://doi.org/10.1016/j.celrep.2018.05.022



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