Fisetin: Fruits and Vegetables: Memory Enhancer, Anticancer, Liver Protector

Fisetin: Fruits and Vegetables: Memory Enhancer, Anticancer, Liver Protector

There's a lot more to fruits and vegetables than just vitamins and nutrients. But it isn't until the past decade that it's flavanol content has been identified.

Fisetin is a flavonol that's naturally present in fruits and vegetables. There's new studies that gives us convincing and powerful scientific insights into how it works to protect our health.

A variety of fruits and vegetables contains fisetin, including:

Cucumber (skin)


Memory Enhancer
Fesitin enhances memory and promotes long term memory retention.

In a study published on Proceedings of the National Academy of Sciences of the United States of America (PNAS), it was found out that "flavonoid fisetin can activate signaling pathways in hippocampal slices that are implicated in the development of long-term memory." Claiming that "No other flavonoid tested was as effective."

Prevents Memory Loss
Fisetin prevents memory loss in Alzheimer's disease by preventing the aggregation of amyloid plaques and exerting anti-inflammatory effect. According to as study published in Neuroscience Letters:

"Fisetin (3,3′,4′,7-tetrahydroxyflavone) has been found to be neuroprotective, induce neuronal differentiation, enhance memory, and inhibit the aggregation of the amyloid β protein (Aβ) that may cause the progressive neuronal loss in Alzheimer's disease."

Promotes Brain recovery
Fisetin promotes glutathione, an antioxidant that fights free radicals and decreases peroxides. Glutathione is the major antioxidant of the nervous system.

In a study published on National Institutes of Health:

"One of the more important observations to emerge from our study is that flavonoids can be added even after the initial ischemic insult and still provide a significant level of protection. Since treatment of stroke often does not begin until several hours after the initial insult, drugs which have long time windows of efficacy are likely to be the most useful."

This is valuable especially to those who suffered ischemia of the brain like post-stroke patients.

Fights Breast Cancer
Fisetin possess an anticancer property against breast cancel cell in a study published on International Journal of Oncology. Fisetin induces natural cell death of tumor cells while not causing toxicity to normal healthy cells. According to this study:

"These data allow us to propose that fisetin appears as a new potential anticancer agent which can be applied to develop a clinical protocol of human breast cancers."

Protects the Liver from Alcohol toxicity
Fisetin has the potential to protect and restore the liver from acute alcohol-induced hepatotoxicity based in a study published in Neuroscience Letters. This involves an experiment with rats:

"Pre-treatment with fisetin (5 and 10 mg/kg) restored the alcohol-induced alterations in liver function, antioxidant defence, histological changes, mitochondrial respiratory enzymes and matrix metalloproteinases activities."

Natural Analgesic
Fisetin  can relieve diabetic neuropathic pain. In a study published in Neuroscience Letters:

"Chronic treatment of diabetic mice with fisetin not only ameliorated the established symptoms of thermal hyperalgesia and mechanical allodynia, but also arrested the development of neuropathic pain when given at low doses."

Note: The above studies are done using animal subjects.